Pub. Date : 2014 Dec 5
PMID : 25315771
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two acidic residues, Glu-48 and Glu-49, of cytochrome b5 (b5) are essential for stimulating the 17,20-lyase activity of cytochrome P450c17 (CYP17A1). | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Two acidic residues, Glu-48 and Glu-49, of cytochrome b5 (b5) are essential for stimulating the 17,20-lyase activity of cytochrome P450c17 (CYP17A1). | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Two acidic residues, Glu-48 and Glu-49, of cytochrome b5 (b5) are essential for stimulating the 17,20-lyase activity of cytochrome P450c17 (CYP17A1). | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Two acidic residues, Glu-48 and Glu-49, of cytochrome b5 (b5) are essential for stimulating the 17,20-lyase activity of cytochrome P450c17 (CYP17A1). | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 5 | Using these two sites of interaction and Glu-48/Glu-49 in b5 as constraints, protein docking calculations based on the crystal structures of the two proteins yielded a structural model of the CYP17A1-b5 complex. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 6 | Using these two sites of interaction and Glu-48/Glu-49 in b5 as constraints, protein docking calculations based on the crystal structures of the two proteins yielded a structural model of the CYP17A1-b5 complex. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 7 | The appositional surfaces include Lys-88, Arg-347, and Arg-358/Arg-449 of CYP17A1, which interact with Glu-61, Glu-42, and Glu-48/Glu-49 of b5, respectively. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 8 | The appositional surfaces include Lys-88, Arg-347, and Arg-358/Arg-449 of CYP17A1, which interact with Glu-61, Glu-42, and Glu-48/Glu-49 of b5, respectively. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 9 | The appositional surfaces include Lys-88, Arg-347, and Arg-358/Arg-449 of CYP17A1, which interact with Glu-61, Glu-42, and Glu-48/Glu-49 of b5, respectively. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 10 | The appositional surfaces include Lys-88, Arg-347, and Arg-358/Arg-449 of CYP17A1, which interact with Glu-61, Glu-42, and Glu-48/Glu-49 of b5, respectively. | Glutamic Acid | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |