Pub. Date : 1989 Nov 1
PMID : 2529923
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We studied native and ASA-treated platelets for their ability to mobilize and to express platelet-vWF in response to adenosine diphosphate (ADP) or thrombin. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 2 | We studied native and ASA-treated platelets for their ability to mobilize and to express platelet-vWF in response to adenosine diphosphate (ADP) or thrombin. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 3 | Measurement of secreted platelet-vWF and beta-thromboglobulin indicated that the increase seen with ADP was largely independent of alpha-granule secretion. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 4 | Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 5 | Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 6 | In contrast, the increase in platelet-vWF that occurred following ADP stimulation of ASA-treated platelets was largely insensitive to GPIIb/IIIa blockade. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |
| 7 | When platelet shape change was prevented by the addition of cytochalasin D, ADP-induced platelet-vWf surface expression on ASA-treated platelets was reduced by more than 80%. | Adenosine Diphosphate | von Willebrand factor | Homo sapiens |