Title : Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study.

Pub. Date : 2014

PMID : 25299054






6 Functional Relationships(s)
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1 Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study. Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
2 Long-term and high-dose treatment with metformin is known to be associated with vitamin B12 deficiency in patients with type 2 diabetes. Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
3 We investigated whether the prevalence of B12 deficiency was different in patients treated with different combination of hypoglycemic agents with metformin during the same time period. Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
4 The prevalence of vitamin B12 deficiency in the metformin-treated patients was significantly higher in the S+M group compared with the I+M group (17.4% vs. 4.2%, P = 0.001). Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
5 In conclusion, our study demonstrated that patients with type 2 diabetes who were treated with metformin combined with sulfonylurea require clinical attention for vitamin B12 deficiency and regular monitoring of their vitamin B12 levels. Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
6 In conclusion, our study demonstrated that patients with type 2 diabetes who were treated with metformin combined with sulfonylurea require clinical attention for vitamin B12 deficiency and regular monitoring of their vitamin B12 levels. Metformin NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens