Title : Inhibitors of Phosphodiesterase 4, but Not Phosphodiesterase 3, Increase β2-Agonist-Induced Expression of Antiinflammatory Mitogen-Activated Protein Kinase Phosphatase 1 in Airway Smooth Muscle Cells.

Pub. Date : 2015 May

PMID : 25296132






1 Functional Relationships(s)
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1 Given that MKP-1 is cAMP dependent, and inhibition of PDE acts to increase beta2-agonist-induced cAMP, it is possible that the presence of PDE inhibitors may enhance beta2-adrenoceptor-mediated responses. Cyclic AMP adrenoceptor beta 2 Homo sapiens