Pub. Date : 2015 Feb
PMID : 25289457
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results suggest that Rac1 oxidation at Cys(18) is a novel posttranslational modification that upregulates Rac1 activity. | Cysteine | Rac family small GTPase 1 | Homo sapiens |
| 2 | Herein, we show that Rac1 contains a redox-sensitive cysteine (Cys(18)) that can be selectively oxidized at physiological pH because of its lowered pKa. | Cysteine | Rac family small GTPase 1 | Homo sapiens |
| 3 | Herein, we show that Rac1 contains a redox-sensitive cysteine (Cys(18)) that can be selectively oxidized at physiological pH because of its lowered pKa. | Cysteine | Rac family small GTPase 1 | Homo sapiens |
| 4 | Oxidation of Cys(18) by glutathione greatly perturbs Rac1 guanine nucleotide binding and promotes nucleotide exchange. | Cysteine | Rac family small GTPase 1 | Homo sapiens |
| 5 | As aspartate substitutions have been previously used to mimic cysteine oxidation, we characterized the biochemical properties of Rac1(C18D). | Cysteine | Rac family small GTPase 1 | Homo sapiens |
| 6 | Our results suggest that Rac1 oxidation at Cys(18) is a novel posttranslational modification that upregulates Rac1 activity. | Cysteine | Rac family small GTPase 1 | Homo sapiens |