Pub. Date : 2013 Dec
PMID : 25278738
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genes encoding the liver cytochrome P-450 (CYP) enzymes that are involved with the metabolism of methadone (CYP2B6, 3A4 and 2C19) were selected and genotyped in this cohort. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | We found that the SNPs on CYP2B6 were associated with plasma S-methadone concentration; SNPs on CYP3A4 were associated with withdrawal symptoms and side effects; and SNPs on CYP2C19 were associated with methadone dose. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | We found that the SNPs on CYP2B6 were associated with plasma S-methadone concentration; SNPs on CYP3A4 were associated with withdrawal symptoms and side effects; and SNPs on CYP2C19 were associated with methadone dose. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |