Title : Differential cytotoxic properties of drugs used for intra-articular injection on human chondrocytes: an experimental in-vitro study.

Pub. Date : 2014 Nov

PMID : 25275343






2 Functional Relationships(s)
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1 INTERVENTION: Incubation of cells with different concentrations of bupivacaine, s-ketamine, morphine and dexamethasone for 1 h. MAIN OUTCOME MEASURES: Fraction of Annexin V positive and Annexin V and propidium iodide double positive cells after 1 h of incubation with tested drug measured by flow cytometry. Bupivacaine annexin A5 Homo sapiens
2 The previously reported chondrotoxicity of bupivacaine (10 to 500 mumol l or 2.8 to 140 mug ml) was confirmed by a concentration-dependent increased staining with Annexin V and propidium iodide. Bupivacaine annexin A5 Homo sapiens