Pub. Date : 2015 Feb
PMID : 25272052
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. | Calcium | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. | Calcium | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. | Calcium | C-C motif chemokine ligand 2 | Homo sapiens |