Title : Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.

Pub. Date : 2014 Dec

PMID : 25271258






1 Functional Relationships(s)
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1 At higher doses/exposure, JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy. Serotonin solute carrier family 6 member 4 Rattus norvegicus