Pub. Date : 2014 Sep 25
PMID : 25254627
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8). | Glutamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8). | Glutamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Glutamine deprivation-induced ER stress triggers colocalization of autophagosomes, lysosomes and the Golgi into a subcellular structure whose integrity is essential for IL-8 secretion. | Glutamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | The stimulatory effect of glutamine restriction on IL-8 production is attributable to depletion of tricarboxylic acid cycle intermediates. | Glutamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | The protein kinase, mTOR, is also colocalized with the lysosomal membrane clusters induced by glutamine deprivation, and inhibition of mTORC1 activity abolishes both endomembrane reorganization and IL-8 secretion. | Glutamine | C-X-C motif chemokine ligand 8 | Homo sapiens |