PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25254627-2 2014 Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8). Glutamine 36-45 C-X-C motif chemokine ligand 8 Homo sapiens 173-186 25254627-2 2014 Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8). Glutamine 36-45 C-X-C motif chemokine ligand 8 Homo sapiens 188-192 25254627-3 2014 Glutamine deprivation-induced ER stress triggers colocalization of autophagosomes, lysosomes and the Golgi into a subcellular structure whose integrity is essential for IL-8 secretion. Glutamine 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 169-173 25254627-4 2014 The stimulatory effect of glutamine restriction on IL-8 production is attributable to depletion of tricarboxylic acid cycle intermediates. Glutamine 26-35 C-X-C motif chemokine ligand 8 Homo sapiens 51-55 25254627-5 2014 The protein kinase, mTOR, is also colocalized with the lysosomal membrane clusters induced by glutamine deprivation, and inhibition of mTORC1 activity abolishes both endomembrane reorganization and IL-8 secretion. Glutamine 94-103 C-X-C motif chemokine ligand 8 Homo sapiens 198-202