Title : A recurrent activating PLCG1 mutation in cardiac angiosarcomas increases apoptosis resistance and invasiveness of endothelial cells.

Pub. Date : 2014 Nov 1

PMID : 25252913






1 Functional Relationships(s)
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1 Ectopic expression of the PLCgamma1-R707Q mutant in endothelial cells revealed reduced PLCgamma1-Y783 phosphorylation with concomitant increased c-RAF/MEK/ERK1/2 phosphorylation, increased IP3 amounts, and increased Ca(2+)-dependent calcineurin activation compared with ectopic expressed PLCgamma1-wild-type. Inositol 1,4,5-Trisphosphate phospholipase C gamma 1 Homo sapiens