Title : New CYP17 hydroxylase inhibitors: synthesis, biological evaluation, QSAR, and molecular docking study of new pregnenolone analogs.

Pub. Date : 2014 Dec

PMID : 25251696






2 Functional Relationships(s)
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1 New CYP17 hydroxylase inhibitors: synthesis, biological evaluation, QSAR, and molecular docking study of new pregnenolone analogs. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Molecular docking studies demonstrated quite similar binding patterns of all new pregnenolone derivatives at the active site of CYP17 through hydrogen bonding and hydrophobic interaction. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens