Title : Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion.

Pub. Date : 1989 Feb 28

PMID : 2524392






2 Functional Relationships(s)
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1 8-OH-DPAT, a selective 5-HT1A agonist, and mCPP, which has preferential affinity for 5-HT1B and 5-HT1C receptors, were studied for their effects on aversive brain stimulation in rats. 1-(3-chlorophenyl)piperazine 5-hydroxytryptamine receptor 1B Rattus norvegicus
2 The proaversive effect of 8-OH-DPAT and the antiaversive effect of mCPP suggest that 5-HT1A and non-5-HT1a (5-HT1B or 5-HT1C) receptors play distinct roles in mechanisms of aversion, perhaps at different locations in the CNS. 1-(3-chlorophenyl)piperazine 5-hydroxytryptamine receptor 1B Rattus norvegicus