Protein Name 5-hydroxytryptamine receptor 1B
Organism Rattus norvegicus
Gene ID 25075
Gene Symbol


UniProt P28564 (5HT1B_RAT)
Relationships Total Number of functionally related compound(s) : 288
Total Number of Articles : 547

5-hydroxytryptamine receptor 1B

Gene Summary

Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Located in plasma membrane. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

  • 5-hydroxytryptamine receptor 1B
  • 5-HT-1B
  • 5-HT1B serotonin receptor
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