Title : Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.

Pub. Date : 2014

PMID : 25242409






2 Functional Relationships(s)
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1 Combined treatment of 3 or 30 mg/kg of genotoxic DEN and PB induced marked increases in altered hepatocellular foci and a DEN dose-dependent increase in the number and area of glutathione S-transferase-placental form (GST-P)-positive foci. Phenobarbital glutathione S-transferase pi 1 Rattus norvegicus
2 Combined treatment of 3 or 30 mg/kg of genotoxic DEN and PB induced marked increases in altered hepatocellular foci and a DEN dose-dependent increase in the number and area of glutathione S-transferase-placental form (GST-P)-positive foci. Phenobarbital glutathione S-transferase pi 1 Rattus norvegicus