Pub. Date : 2014 Oct 29
PMID : 25236584
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. | Calcifediol | interleukin 10 | Homo sapiens |
| 2 | However, like calcitriol, calcidiol not only exerted an inhibitory effect on DC maturation and cytokine production, and primed DCs to promote the development of suppressive IL-10-producing Treg cells. | Calcifediol | interleukin 10 | Homo sapiens |
| 3 | Strikingly, in contrast to the population of IL-10-producing Treg cells induced by calcitriol-primed DCs, the IL-10-producing Treg cells induced by calcidiol-primed DCs exhibited sustained IFN-gamma production in face of their suppressive capacity. | Calcifediol | interleukin 10 | Homo sapiens |