Pub. Date : 2014 Dec
PMID : 25230779
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric cancer cells. | Fluorouracil | prominin 1 | Homo sapiens |
| 2 | Hence, the present study investigated the function of CD133 in 5-FU resistance in human GC cells. | Fluorouracil | prominin 1 | Homo sapiens |
| 3 | Furthermore, CD133 silencing enhanced 5-FU cytotoxicity and apoptotic characteristics, whereas CD133 overexpression increased 5-FU resistance. | Fluorouracil | prominin 1 | Homo sapiens |
| 4 | Furthermore, CD133 silencing enhanced 5-FU cytotoxicity and apoptotic characteristics, whereas CD133 overexpression increased 5-FU resistance. | Fluorouracil | prominin 1 | Homo sapiens |
| 5 | Notably, Akt inhibition by LY294002 restored the 5-FU cytotoxicity suppressed by CD133 overexpression, while Akt activation by epidermal growth factor reversed the 5-FU cytotoxicity enhanced by CD133 silencing. | Fluorouracil | prominin 1 | Homo sapiens |
| 6 | Therefore, CD133 may inhibit 5-FU-induced apoptosis by regulating the expression of P-gp and Bcl-2 family mediated by phosphoinositide 3-kinase/Akt/p70S6K pathway in GC cells. | Fluorouracil | prominin 1 | Homo sapiens |