Protein Name prominin 1
Organism Homo sapiens
Gene ID 8842
Gene Symbol


UniProt O43490 (PROM1_HUMAN), A0A0A0N0M1 (A0A0A0N0M1_HUMAN)
Relationships Total Number of functionally related compound(s) : 522
Total Number of Articles : 713

prominin 1

Gene Summary

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

  • prominin-1
  • AC133 antigen
  • Retinitis pigmentosa 41, Cone-rod dystrophy 12
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