Pub. Date : 2014 Dec
PMID : 25224579
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vasoconstriction induced by dexmedetomidine, a highly selective alpha-2 adrenoceptor agonist, mainly involves c-Jun NH2 -terminal kinase (JNK) phosphorylation in the isolated endothelium-denuded aorta. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | We carried out an in vitro study to determine the main arachidonic acid metabolic pathway that is involved in dexmedetomidine-induced JNK activation. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | SP600125, rauwolscine, quinacrine dihydrochloride, nordihydroguaiaretic acid, AA-861, phenidone and GF 109203X attenuated dexmedetomidine-induced JNK phosphorylation. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | Thus, dexmedetomidine-induced alpha-2 adrenoceptor-mediated contraction is mediated mainly by 5-LOX and partially by COX-2, which leads to JNK phosphorylation. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |