Pub. Date : 2014 Dec
PMID : 25210004
2 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). | halopemide | phospholipase D2 | Homo sapiens | ||
2 | Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). | halopemide | phospholipase D2 | Homo sapiens |