Title : Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Pub. Date : 2014 Nov

PMID : 25205677






1 Functional Relationships(s)
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1 Coapplication of 50 muM PYD-106 with a maximally effective concentration of glutamate and glycine increases the response of GluN1/GluN2C NMDA receptors in HEK-293 cells to 221% of that obtained in the absence of PYD (taken as 100%). Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens