Pub. Date : 2014 Sep 11
PMID : 25199829
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MEK inhibition induces RAS activation and BRAF-RAF1 dimerization and sustains MEK-ERK signaling, which is responsible for intrinsic resistance to selumetinib. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |