Title : Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression.

Pub. Date : 2015 Feb

PMID : 25199511






3 Functional Relationships(s)
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1 The results showed that oral CAFs expressed a higher level of FAK than normal human gingival fibroblasts (HGFs), and the conditioned medium (CM) of CAFs could induce the invasion and migration of SCC-25, one oral squamous carcinoma cell line. cafs protein tyrosine kinase 2 Homo sapiens
2 The results showed that oral CAFs expressed a higher level of FAK than normal human gingival fibroblasts (HGFs), and the conditioned medium (CM) of CAFs could induce the invasion and migration of SCC-25, one oral squamous carcinoma cell line. cafs protein tyrosine kinase 2 Homo sapiens
3 Therefore, our findings indicated that targeting FAK in CAFs might be a promising strategy for the treatment of OSCC in the future. cafs protein tyrosine kinase 2 Homo sapiens