Title : Inhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate.

Pub. Date : 2014 Aug

PMID : 25197954






4 Functional Relationships(s)
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1 Inhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate. allyl isothiocyanate cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 In this study, we found that allyl isothiocyanate reduced catalytic activity, messenger ribonucleic acid, and protein expression of cytochrome P450 2C9 in HepaRG cells. allyl isothiocyanate cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 The decrease of cytochrome P450 2C9 expression and activity mediated by allyl isothiocyanate suggested that this agent could alter the metabolism of drugs metabolized by cytochrome P450 2C9. allyl isothiocyanate cytochrome P450 family 2 subfamily C member 9 Homo sapiens
4 The decrease of cytochrome P450 2C9 expression and activity mediated by allyl isothiocyanate suggested that this agent could alter the metabolism of drugs metabolized by cytochrome P450 2C9. allyl isothiocyanate cytochrome P450 family 2 subfamily C member 9 Homo sapiens