Title : JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis.

Pub. Date : 2014 Nov 6

PMID : 25193869






1 Functional Relationships(s)
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1 The in vitro treatment of splenic and peripheral blood MF CD34(+) cells with the JAK1/2/3 inhibitor, AZD1480, reduced the absolute number of CD34(+), CD34(+)CD90(+), and CD34(+)CXCR4(+) cells as well as assayable hematopoietic progenitor cells (HPCs) irrespective of the JAK2 and calreticulin mutational status. AZD 1480 Janus kinase 1 Homo sapiens