Title : Reversible epigenetic regulation of 14-3-3σ expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1.

Pub. Date : 2014 Nov

PMID : 25189999






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1 Reversible epigenetic regulation of 14-3-3sigma expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. gemcitabine stratifin Homo sapiens
2 To understand acquired gemcitabine resistance, we generated a gemcitabine-resistant pancreatic cancer cell line using stepwise selection and found that, in addition to the known mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dramatically upregulated, and that 14-3-3sigma overexpression contributes to the acquired resistance to gemcitabine and cross-resistance to cytarabine. gemcitabine stratifin Homo sapiens
3 To understand acquired gemcitabine resistance, we generated a gemcitabine-resistant pancreatic cancer cell line using stepwise selection and found that, in addition to the known mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dramatically upregulated, and that 14-3-3sigma overexpression contributes to the acquired resistance to gemcitabine and cross-resistance to cytarabine. gemcitabine stratifin Homo sapiens
4 To understand acquired gemcitabine resistance, we generated a gemcitabine-resistant pancreatic cancer cell line using stepwise selection and found that, in addition to the known mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dramatically upregulated, and that 14-3-3sigma overexpression contributes to the acquired resistance to gemcitabine and cross-resistance to cytarabine. gemcitabine stratifin Homo sapiens
5 To understand acquired gemcitabine resistance, we generated a gemcitabine-resistant pancreatic cancer cell line using stepwise selection and found that, in addition to the known mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dramatically upregulated, and that 14-3-3sigma overexpression contributes to the acquired resistance to gemcitabine and cross-resistance to cytarabine. gemcitabine stratifin Homo sapiens
6 To understand acquired gemcitabine resistance, we generated a gemcitabine-resistant pancreatic cancer cell line using stepwise selection and found that, in addition to the known mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dramatically upregulated, and that 14-3-3sigma overexpression contributes to the acquired resistance to gemcitabine and cross-resistance to cytarabine. gemcitabine stratifin Homo sapiens
7 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens
8 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens
9 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens
10 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens
11 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens
12 We also found that the increased 14-3-3sigma expression in the gemcitabine-resistant cells is due to demethylation of the 14-3-3sigma gene during gemcitabine selection, which could be partially reversed with removal of the gemcitabine selection pressure. gemcitabine stratifin Homo sapiens