Pub. Date : 2014
PMID : 25184316
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin (100 nM) transiently (15 min) inhibited the nuclear translocation of both NF-kappaB dimers (p50/p50, p50/RelA) and, after 60 min, increased the activation of p50/RelA. | Melatonin | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |
| 2 | Melatonin (100 nM) transiently (15 min) inhibited the nuclear translocation of both NF-kappaB dimers (p50/p50, p50/RelA) and, after 60 min, increased the activation of p50/RelA. | Melatonin | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |
| 3 | Melatonin-induced p50/RelA activity in naive cells resulted in the transcription of inducible nitric oxide synthase (iNOS) and the production of NO. | Melatonin | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |
| 4 | Otherwise, in cultures treated with LPS, melatonin blocked the LPS-induced activation of p50/RelA and the reduction in p50/p50 levels and inhibited iNOS expression and NO synthesis. | Melatonin | RELA proto-oncogene, NF-kB subunit | Rattus norvegicus |