Title : The immunobiology of cobalt: demonstration of a potential aetiology for inflammatory pseudotumours after metal-on-metal replacement of the hip.

Pub. Date : 2014 Sep

PMID : 25183586






4 Functional Relationships(s)
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Protein Name
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1 Cobalt ions activate human toll-like receptor 4 (TLR4), which normally responds to bacterial lipopolysaccharide (LPS) in sepsis. Cobalt toll like receptor 4 Homo sapiens
2 Cobalt ions activate human toll-like receptor 4 (TLR4), which normally responds to bacterial lipopolysaccharide (LPS) in sepsis. Cobalt toll like receptor 4 Homo sapiens
3 Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression. Cobalt toll like receptor 4 Homo sapiens
4 These findings suggest that cobalt ions induce inflammation similar to that observed during sepsis by the simultaneous activation of two TLR4-mediated signalling pathways. Cobalt toll like receptor 4 Homo sapiens