Title : The immunobiology of cobalt: demonstration of a potential aetiology for inflammatory pseudotumours after metal-on-metal replacement of the hip.

Pub. Date : 2014 Sep

PMID : 25183586






4 Functional Relationships(s)
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1 This study was designed to determine whether cobalt induces a similar inflammatory response to LPS by promoting the expression of IL-8 and CXCL10. Cobalt C-X-C motif chemokine ligand 10 Homo sapiens
2 Cobalt-treated macrophages showed a 60-fold increase in IL-8 mRNA, and an eightfold increase in production of the mature chemokine (both p < 0.001); expression of the CXCL10 gene and protein was also significantly increased by cobalt (both p < 0.001). Cobalt C-X-C motif chemokine ligand 10 Homo sapiens
3 Cobalt-treated macrophages showed a 60-fold increase in IL-8 mRNA, and an eightfold increase in production of the mature chemokine (both p < 0.001); expression of the CXCL10 gene and protein was also significantly increased by cobalt (both p < 0.001). Cobalt C-X-C motif chemokine ligand 10 Homo sapiens
4 Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression. Cobalt C-X-C motif chemokine ligand 10 Homo sapiens