Pub. Date : 2014 Nov
PMID : 25174355
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. | Arsenic Trioxide | E2F transcription factor 1 | Homo sapiens |
| 2 | Using the H358 xenograft model, the tumor growth was suppressed in the ATO treatment group during 8 days of treatment, associated with downregulation of E2F1 and upregulation of truncated Bid and cleaved caspase-3. | Arsenic Trioxide | E2F transcription factor 1 | Homo sapiens |
| 3 | In conclusion, ATO has potent in vitro and in vivo activity in lung adenocarcinoma, partially mediated through E2F1 downregulation and apoptosis. | Arsenic Trioxide | E2F transcription factor 1 | Homo sapiens |