Title : Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors.

Pub. Date : 2014 Sep 15

PMID : 25172421






1 Functional Relationships(s)
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1 In the molecular modelling study, compound 9i was bound in to the active pocket of EGFR with four hydrogen bonds and two pi-cation interactions having minimum binding energy DeltaGb=-54.4 kcal/mol. Hydrogen epidermal growth factor receptor Homo sapiens