Title : Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle.

Pub. Date : 2014 Nov 15

PMID : 25172224






2 Functional Relationships(s)
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Protein Name
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1 Akt inhibition both attenuated the increase in Ser(485/491) p-AMPK caused by insulin, and prevented the decrease in AMPK activity. Serine AKT serine/threonine kinase 1 Rattus norvegicus
2 Similarly, the growth factor IGF-1 stimulated Ser(485/491) AMPK phosphorylation, and this too was blunted by inhibition of Akt. Serine AKT serine/threonine kinase 1 Rattus norvegicus