Pub. Date : 2015
PMID : 25171714
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The histidine composition of the amyloid-beta domain, but not the E1 copper binding domain, modulates beta-secretase processing of amyloid-beta protein precursor in Alzheimer"s disease. | Histidine | amyloid beta precursor protein | Homo sapiens |
2 | The histidine composition of the amyloid-beta domain, but not the E1 copper binding domain, modulates beta-secretase processing of amyloid-beta protein precursor in Alzheimer"s disease. | Histidine | amyloid beta precursor protein | Homo sapiens |
3 | We have investigated the role of histidine residues within the extracellular E1 copper binding and Abeta domains of AbetaPP in its proteolysis. | Histidine | amyloid beta precursor protein | Homo sapiens |
4 | Mutation of histidine 14 within the Abeta-domain specifically down-regulated beta-secretase processing without impacting on non-amyloidogenic proteolysis. | Histidine | amyloid beta precursor protein | Homo sapiens |
5 | Understanding how histidine 14 participates in AbetaPP proteolysis may reveal new intervention points for AD treatments. | Histidine | amyloid beta precursor protein | Homo sapiens |