Title : Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo.

Pub. Date : 2014 Nov

PMID : 25169829






2 Functional Relationships(s)
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1 RESULTS: Hinokitiol inhibited IL-1beta-stimulated MMP-1,-3 and -13 expressions and IL-1beta-induced activation of intracellular beta-catenin proteins in cultured chondrocytes. beta-thujaplicin catenin beta 1 Rattus norvegicus
2 CONCLUSIONS: Hinokitiol is an effective anti-inflammatory reagent that acts by inhibiting the Wnt/beta-catenin signaling pathway and could be a promising therapeutic agent for the prevention and treatment of osteoarthritis. beta-thujaplicin catenin beta 1 Rattus norvegicus