Title : Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.

Pub. Date : 2015 Feb

PMID : 25159194






4 Functional Relationships(s)
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Protein Name
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1 Oxidative metabolism of pomalidomide was predominately mediated by CYP1A2 and CYP3A4, and pomalidomide was shown to be a P-gp substrate. pomalidomide cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 Co-administration of pomalidomide with fluvoxamine (CYP1A2 inhibitor) in the presence of ketoconazole approximately doubled pomalidomide exposure. pomalidomide cytochrome P450 family 1 subfamily A member 2 Homo sapiens
3 Co-administration of pomalidomide with fluvoxamine (CYP1A2 inhibitor) in the presence of ketoconazole approximately doubled pomalidomide exposure. pomalidomide cytochrome P450 family 1 subfamily A member 2 Homo sapiens
4 Pomalidomide dose should be reduced by 50% if co-administered with strong CYP1A2 inhibitors and strong CYP3A/P-gp inhibitors. pomalidomide cytochrome P450 family 1 subfamily A member 2 Homo sapiens