Title : Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis.

Pub. Date : 2014 Sep 15

PMID : 25152164






1 Functional Relationships(s)
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1 Mechanistically, SQS contributed to a lipid-raft-localized enrichment of tumor necrosis factor receptor 1 in a cholesterol-dependent manner, which resulted in the enhancement of nuclear factor-kappaB activation leading to matrix metallopeptidase 1 up-regulation. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens