Title : ╬▓TrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.

Pub. Date : 2014 Sep 15

PMID : 25149538






1 Functional Relationships(s)
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1 Specifically, treatment with the chemotherapeutic agent doxorubicin in certain cell lines provokes CDK1 degradation and induces apoptosis, whereas in others it inhibits destruction of the protein. Doxorubicin cyclin dependent kinase 1 Homo sapiens