Title : Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction.

Pub. Date : 2014

PMID : 25132913






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1 This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on SA-miRNAs (miR-20a, miR-24, miR-34a, miR-106a, and miR-449a) and established target genes of miR-34a (CCND1, CDK4, and SIRT1) during replicative senescence of human diploid fibroblasts (HDFs). Tocotrienols sirtuin 1 Homo sapiens