Pub. Date : 2014 Jun
PMID : 25126374
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salsalate belongs to the salicylate drug class, which has been shown to inhibit I-kappaB kinase, thereby inhibiting the nuclear factor-kappaB (NF-kappaB) cascade and decreasing the production of inflammatory cytokines, as well as decreasing insulin resistance. | Salicylates | insulin | Homo sapiens |
| 2 | Recent short-term clinical trials have shown that 3 g to 4.5 g of salicylate therapy daily has the ability to lower insulin resistance and to reduce the levels of glucose, triglycerides, and free fatty acid concentrations through regulation of the I-kappaB kinase beta/NF-kappaB pathway, with few if any side effects. | Salicylates | insulin | Homo sapiens |