Title : Global Toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy.

Pub. Date : 2014 Nov-Dec

PMID : 25116192






1 Functional Relationships(s)
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1 RESULTS: Compared to C, STZ-WT mice had significantly increased macrophage and TLR4 immunostaining in kidney, significant increases in MyD88, Interferon Regulatory Factor-3, NFKappaB activity, TNF-Alpha, IL-6, and MCP-1; all these were significantly decreased in the STZ-TLR4KO compared to STZ-WT mice. Streptozocin interleukin 6 Mus musculus