Pub. Date : 2014 Oct
PMID : 25115571
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In Niemann-Pick type C (NPC) disease, loss-of-function mutations in either NPC1 or NPC2 result in progressive accumulation of unesterified cholesterol (UC) and glycosphingolipids in all organs, leading to neurodegeneration, pulmonary dysfunction and sometimes liver failure. | Cholesterol | NPC intracellular cholesterol transporter 1 | Mus musculus |
2 | There was a transient increase in biliary cholesterol concentration in Npc1(-/-) mice after 2HPbetaCD. | Cholesterol | NPC intracellular cholesterol transporter 1 | Mus musculus |