| Protein Name | NPC intracellular cholesterol transporter 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18145 |
| Gene Symbol | Npc1 |
| UniProt | O35604 (NPC1_MOUSE), Q7TMD4 (Q7TMD4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
111
Total Number of Articles : 229 |
Description |
NPC intracellular cholesterol transporter 1 |
| Gene Summary |
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Involved in several processes, including cholesterol homeostasis; protein glycosylation; and symbiont entry into host cell. Acts upstream of or within several processes, including adult walking behavior; cholesterol efflux; and cyclodextrin metabolic process. Located in several cellular components, including lysosome; membrane raft; and nuclear envelope. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and stomach. Used to study Niemann-Pick disease and Niemann-Pick disease type C1. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Jul 2025] |
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