Title : Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core.

Pub. Date : 2014

PMID : 25099343






2 Functional Relationships(s)
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1 Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core. pyrrolo(2, 3-b)pyridine acyl-CoA wax alcohol acyltransferase 1 Homo sapiens
2 Here, using an in vitro screen of 20000 molecules, we identified a class of compounds with a substituted 1H-pyrrolo[2,3-b]pyridine core which proved to be potent and selective inhibitors of human DGAT2. pyrrolo(2, 3-b)pyridine acyl-CoA wax alcohol acyltransferase 1 Homo sapiens