Pub. Date : 2014 Sep 26
PMID : 25096579
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 2 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 3 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 4 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 5 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 6 | In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 7 | Here, we adapt recently developed single-bond chemistry techniques to study individual disulfide isomerization reactions in hSOD1. | Disulfides | superoxide dismutase 1 | Homo sapiens |
| 8 | Mechanical unfolding of hSOD1 leads to the formation of a polypeptide loop held by the disulfide. | Disulfides | superoxide dismutase 1 | Homo sapiens |