Pub. Date : 2014 Oct
PMID : 25095742
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Docosahexanoic acid antagonizes TNF-alpha-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 2 | OBJECTIVE: It was previously reported that docosahexanoic acid (DHA) reduces TNF-alpha-induced necrosis in L929 cells. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 3 | OBJECTIVE: It was previously reported that docosahexanoic acid (DHA) reduces TNF-alpha-induced necrosis in L929 cells. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 4 | The present study was designed to investigate cellular and biochemical mechanisms underlying the attenuation of TNF-alpha-induced necroptosis by DHA in L929 cells. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 5 | METHODS: L929 cells were pre-treated with DHA prior to exposure to TNF-alpha, zVAD, or Necrostatin-1 (Nec-1). | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 6 | DHA attenuated multiple biochemical events associated with TNF-alpha-induced necroptosis, including ROS generation, ceramide production, lysosomal dysfunction, cathepsin L activation, and autophagic features. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 7 | CONCLUSIONS: DHA effectively attenuates TNF-alpha-induced necroptosis and autophagy, most likely via its ability to inhibit TNF-alpha-induced sphingolipid metabolism and oxidative stress. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |
| 8 | CONCLUSIONS: DHA effectively attenuates TNF-alpha-induced necroptosis and autophagy, most likely via its ability to inhibit TNF-alpha-induced sphingolipid metabolism and oxidative stress. | Docosahexaenoic Acids | tumor necrosis factor | Mus musculus |