Pub. Date : 2014
PMID : 25093162
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha-induced necroptosis of HT-22 cells is largely independent of both ROS accumulation and calcium influx although these events have been shown to be critical for necroptosis in certain cell lines. | ros | tumor necrosis factor | Mus musculus |
| 2 | Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx. | ros | tumor necrosis factor | Mus musculus |
| 3 | Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx. | ros | tumor necrosis factor | Mus musculus |