Title : Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor.

Pub. Date : 2014 Oct 1

PMID : 25085890






2 Functional Relationships(s)
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1 Maximal concentrations of the MOR-selective agonist DAMGO induced outward currents in POMC neurons that were completely reversed by a relatively high concentration of nor-BNI. norbinaltorphimine pro-opiomelanocortin-alpha Mus musculus
2 Experiments using a half-maximal concentration of DAMGO demonstrate that nor-BNI must be used at concentrations <100 nm to avoid non-specific actions of the antagonist at MORs located on POMC neurons. norbinaltorphimine pro-opiomelanocortin-alpha Mus musculus