Title : Cbl negatively regulates erythropoietin-induced growth and survival signaling through the proteasomal degradation of Src kinase.

Pub. Date : 2014 Dec

PMID : 25084697






2 Functional Relationships(s)
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1 In addition, the co-expression experiments and in vitro kinase assay demonstrated that the EPO-induced tyrosine phosphorylation and ubiquitination of Cbl were dependent on the kinase activity of Src but not Jak2. Tyrosine Cbl proto-oncogene Homo sapiens
2 Thus, Cbl negatively regulates EPO signaling mainly through the proteasome-dependent degradation of Src, and the E3 ligase activity of Cbl and its tyrosine phosphorylation are regulated by Src but not Jak2. Tyrosine Cbl proto-oncogene Homo sapiens