Title : Cytomegalovirus upregulates expression of CCR5 in central memory cord blood mononuclear cells, which may facilitate in utero HIV type 1 transmission.

Pub. Date : 2015 Jan 15

PMID : 25081935






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Unstimulated CD4(+) CBMCs that lack CCR5/CD45RO showed reduced levels of HIV-1 infection. cbmcs C-C motif chemokine receptor 5 Homo sapiens
2 However, upon in vitro stimulation with CMV, CBMCs undergo increased proliferation to upregulate the fraction of T central memory cells and expression of CCR5, which enhances susceptibility to HIV-1 infection in vitro. cbmcs C-C motif chemokine receptor 5 Homo sapiens